- BSc (Hons), Neuroscience and Mental Health, Carleton University (2022)
- Contact: zacharysilver@cmail.carleton.ca OR zacharysilver6@gmail.com
Research Interest/Focus
My research focuses on the interaction between ghrelin and a specialized glial cell type called tanycytes. In the hypothalamus, tanycytes can be found at the ventral aspect of the third ventricle right next to the median eminence. Here, they regulate the access of bloodborne substances to the cerebrospinal fluid (CSF) through the formation of the blood-CSF barrier, and also regulate the activity of nearby hypothalamic circuits through direct interaction with neighbouring neurons. Through these means, tanycytes have been implicated in the control of energy balance. My research is specifically examining the role of tanycytes in the transportation of ghrelin to its hypothalamic targets, and how they may mediate the orexigenic effect of ghrelin.
Publications
Martins, M. G., Silver, Z., Ayoub, K., Hyland, L., Woodside, B., Kiss, A. C. I., & Abizaid, A. (2023). Maternal glucose intolerance during pregnancy affects offspring POMC expression and results in adult metabolic alterations in a sex-dependent manner. Frontiers in Endocrinology, 14, eArticle 1189207. https://doi.org/10.3389/fendo.2023.1189207
Smith, A., Hyland, L., Al-Ansari, H., Watts, B., Silver, Z., Wang, L., Dahir, M., Akgun, A., Telfer, A., & Abizaid, A. (2023). Metabolic, neuroendocrine and behavioral effects of social defeat in male and female mice using the chronic non-discriminatory social defeat stress model. Hormones and Behavior, 155, eArticle 105412. https://doi.org/10.1016/j.yhbeh.2023.105412
Deng, J., Zhou, F., Heybati, K., Zuo, Q. K., Ali, S., Hou, W., Wong, C. Y., Ba Ramaraju, H., Chang, O., Dhivagaran, T., & Silver, Z. (2022). Efficacy and safety of corticosteroid regimens for the treatment of hospitalized COVID-19 patients: a meta-analysis. Future Virology, 17(7), 463-489.
Deng, J., Zhou, F., Hou, W., Heybati, K., Ali, S., Chang, O., Silver, Z., Dhivagaran, T., Ba Ramaraju, H., Wong, C. Y., Kang Zuo, Q., Lapshina, E., & Mellet, M. (2022). Efficacy of lopinavir–ritonavir combination therapy for the treatment of hospitalized COVID-19 patients: a meta-analysis. Future Virology, 17(3).
Silver, Z., Abbott-Tate, S., Hyland, L., Sherratt, F., Woodside, B., & Abizaid, A. (2021). Ghrelin receptor signaling is not required for glucocorticoid-induced obesity in female mice. Journal of Endocrinology, 250(2), 37-48.
Deng, J., Zhou, F., Hou, W., Silver, Z., Yi Wong, C., Chang, O., Drakos, A., Kang Zuo, Q., & Huang, E. (2021). The prevalence of depressive symptoms, anxiety symptoms and sleep disturbance in higher education students during the COVID-19 pandemic: A systematic review and meta-analysis. Psychiatry Research, 301, eArticle 113863. https://doi.org/10.1016/j.psychres.2021.113863
Deng, J., Zhou, F., Heybati, K., Ali, S., Zuo, Q. K., Hou, W., Dhivagaran, T., Ba Ramaraju, H., Chang, O., Wong, C. Y., & Silver, Z. (2021). Efficacy of chloroquine and hydroxychloroquine for the treatment of hospitalized COVID-19 patients: a meta-analysis. Future Virology, 17(2).
Deng, J., Silver, Z., Huang, E., Zheng, E., Kavanagh, K., Wen, A., Cheng, W., Dobransky, J., Sanger, S., & Grammatopoulos, G. (2020). Pharmacological prevention of fractures in patients undergoing glucocorticoid therapies: a systematic review and network meta-analysis. Rheumatology, 60(2), 649-657.
Deng, J., Zhou, F., Hou, W., Silver, Z., Yi Wong, C., Chang, O., Huang, E., & Kang Zuo, Q. (2020). The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: a meta-analysis. Annals of the New York Academy of Sciences, 1486(1), 90-111. https://doi.org/10.1111/nyas.14506
Deng, J., Silver, Z., Huang, E., Zheng, E., Kavanagh, K., & Panicker, J. (2020). The effect of calcium and vitamin D compounds on bone mineral density in patients undergoing glucocorticoid therapies: a network meta-analysis. Clinical Rheumatology, 40(2), 725-734. https://doi.org/10.1007/s10067-020-05294-y
Outside of the Lab
When I am not in the lab I like to run, lift weights, read comic books, watch sports, and spend time
with friends.