Zack Patterson

  • PhD – Neuroscience, Carleton University
  • B.Sc. – Integrated Science, Carleton University
  • Chief Financial Officer – CHANCE Foundation
  • President (2012/2013) – Society for Neuroscience, Ottawa Chapter
  • Treasurer (2012/2013) – Society for Neuroscience, Ottawa Chapter
  • Contact: email hidden; JavaScript is required

Research

My research involves the orexigenic gut-brain peptide ghrelin and its roles in contributing to stress induced metabolic and hormonal dysfunctions. Early experiments from our lab have shown that ghrelin levels rise in response to stress and that interfering with ghrelin signaling during stress results in altered metabolic responses. We, and others, have shown that animals exposed to chronic social defeat stress develop a phenotype reminiscent of metabolic syndrome. Recently, we demonstrated that interfering with ghrelin signaling (genetically or pharmacologically) in animals subjected to a chronic social defeat stress paradigm prevents the development of stress-induced metabolic syndrome-like phenotypes. Currently, we are investigating the physiological role of ghrelin within the context of the stress response and how ghrelin is capable of dictating the real estate from which an organism gathers resources during times of high-energy demand.

Publications

Agil, R., Patterson, ZR, Mackay, H, Abizaid, A., and Hosseinian, F. (2016). Triticale Bran Alkylresorcinols Enhance Resistance to Oxidative Stress in Mice Fed a High-Fat Diet. Foods 5 (1), 5.

Wellman, M.K., Patterson, Z.R., MacKay, H., Darling, J.E., Mani, B.K. Zigman, J.M, Hougland, J.L. & Abizaid, A. (2015). Novel regulator of acylated ghrelin, CF801, reduces weight gain, rebound feeding after a fast, and adiposity in mice. Frontiers in Systems and Translational Endocrinology, Manuscript Accepted.

Patton, D.F, Katsuyama, A. M., Pavlovski, I., Michalik, M., Patterson, Z.R., Parfyonov, M., Smit, A.N., Marchant, E.G., Chung, J., Abizaid, A., Storch, K-F., de la Iglesia, H., and Mistlberger, R.E. (2014) Circadian Mechanisms of Food Anticipatory Rhythms in Rats Fed Once or Twice Daily: Clock Gene and Endocrine Correlates. PloS One, 9 (12), e112451. DOI: 10.1371/journal.pone.0112451

Jodayree, S., Patterson, Z.R., MacKay, H., Abizaid, A. & Tsopmo, A. (2014) Blood and Liver Antioxidant Capacity of Mice Fed High Fat Diet Supplemented with Digested Oat Bran Proteins. International Journal of Food Science and Nutrition Engineering 4 (1), 9-14.

MacKay, H.A., Khazall, R., Patterson, Z.R., Wellman, M.K., Abizaid, A. (2013). Rats perinatally exposed to food restriction and high-fat diet show differences in adipose tissue gene expression under chronic caloric restriction. Adipocyte. 2(4): 1-9.

Patterson ZR, Ducharme R, Anisman H & Abizaid A. (2010) Altered Metabolic and Neurochemical Responses to Chronic Unpredictable Stressors in Ghrelin Receptor Deficient Mice. European Journal of Neuroscience.

Patterson ZR, Blum ID, Khazall R, Lamont EW, Sleeman MW, Horvath TL & Abizaid A. (2009) Reduced Anticipatory Locomotor Activity to Scheduled Meals in Ghrelin Receptor Deficient Mice. Neuroscience.

Poster Presentations

Patterson ZR, Ducharme R., Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Contributes to the Development of Stress-Induced Metabolic Alterations Following Chronic Stress. Society for Neuroscience, 2009. Chicago, IL, USA.

Patterson ZR, Ducharme R., Khazall RK, Anisman H, Abizaid A. Ghrelin Mediates Metabolic Alterations Associated with Chronic Exposure to Stress. Society for Behavioral Neuroendocrinology Conference, 2009. East Lansing, MI, USA.

Blum ID, Patterson ZR, Lamont EW & Abizaid A. Time for Lunch! Ghrelin is an important signal for food anticipation. Society for Behavioral Neuroendocrinology Conference, 2009. East Lansing, MI, USA.

Patterson ZR, Ducharme R., Khazall RK, Anisman H, Abizaid A. Ghrelin Mediates Metabolic Alterations Associated with Chronic Exposure to Stress. Young Researchers Forum – Institute of Mental Health Research, 2009. Ottawa, ON, Canada.

Blum ID, Patterson ZR, Lamont EW & Abizaid A. Time for Lunch! Ghrelin is an important signal for food anticipation. Young Researchers Forum – Institute of Mental Health Research, 2009. Ottawa, ON, Canada.

Patterson ZR, Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Mediates Vulnerability to Stress Induced Metabolic & Hormonal Dysfunction. Canadian Neuroscience Society, 2010. Ottawa, ON, Canada.

Khazall RK, Wellman MK, Patterson ZR, Lamont EW, Mackay HA, Anisman H & Abizaid A. Effects of Ghrelin on Metabolic Processes in Response to Chronic Social Stress. Canadian Neuroscience Society, 2010. Ottawa, ON, Canada.

Patterson ZR, Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Mediates Vulnerability to Stress Induced Metabolic & Hormonal Dysfunction. Canadian Obesity Summit, 2010. Ottawa, ON.

Patterson ZR, Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Mediates Vulnerability to Stress Induced Metabolic & Hormonal Dysfunction. Society for Neuroscience, 2010. San Diego, California, USA.

Patterson ZR, Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Mediates Vulnerability to Stress Induced Metabolic & Hormonal Dysfunction. Society for Behavioral Neuroendocrinology, 2010. Toronto, ON, Canada.

Mackay JC, Patterson ZR, James JS, KentnP, Abizaid A & Merali Z. The Impact of Unpredictable Chronic Social Defeat on Palatable Feeding & Behavioural Markers of Depression & Anxiety. International Behavioral Neuroscience Society. Steamboat Springs, Colorado, USA.

Patterson ZR, Khazall,RK, Sleeman MW, Anisman H, Abizaid A. Differential Metabolic Profiles between Wild-Type and GHSR KO Mice Following Chronic Social Defeat Stress. Society for Neuroscience, 2011. Washington, DC, USA.

Mackay HM, Khazall R, Patterson ZR, Wellman M & Abizaid, A. Early Postnatal Over- or Under-Nutrition Affects FTO Expression in Adult Offspring. Young Researchers Forum – Institute of Mental Health Research, 2011. Ottawa, ON, Canada.

Mackay HM, Khazall R, Patterson ZR, Wellman M & Abizaid, A. Early Postnatal Over- or Under-Nutrition Affects FTO Expression in Adult Offspring. Young Canadian Obesity Summit Annual Meeting, Montreal, QU, Canada.

Smith CA, Wartman BC, Blum ID, Khazall RK, Moloney K, Patterson ZR, Wellman MK & Abizaid A.Neuroscience and the Arts: Society for Neuroscience Ottawa Chapter. Society for Neuroscience, 2011. Washington, DC, USA.

Invited Talks

Patterson, ZR – Ghrelin: A Hormonal Target for the Prevention of Stress Induced Metabolic Dysfunction.Young Researchers Forum – Institute of Mental Health Research, 2010. Ottawa, ON, Canada.

Patterson, ZR – Contributions of Ghrelin to Appetitive Behaviors Preceding a Meal. Canadian Society for Brain, Behavioral and Cognitive Sciences, 2011. Winnipeg, MN, Canada.

Awards

  • NSERC – Alexander Graham Bell Canadian Graduate Scholarship
  • Best Oral Presentation – Young Researchers Forum – Institute of Mental Health Research. 2010. Ottawa, ON.
  • Best ‘Basic Research’ Poster Presentation – Canadian Obesity Summit Annual Meeting, 2010. Ottawa, ON.