Stephanie Rosenbaum

  • Master’s Student
  • BSc in Anatomy and Cell Biology at McGill
  • BSc in Behavioral Neurosciences at Concordia

Research

My research focuses on Ghrelin; a gut-derived orexigenic peptide that regulates food intake and energy homeostasis in the hypothalamus. Recent studies including some NSERC funded work from our lab, shows that ghrelin has been shown to play an important role in extra-hypothalamic sites, such as those involved in the motivation of food-seeking behaviors and rewarding value of palatable foods (King et al, 2011). Furthermore, studies in rodents show that central or peripheral ghrelin administration lead to an increase of dopamine (DA) release in the nucleus accumbens (NAcc) by neurons projecting from the Ventral Tegmental Area (VTA; Abizaid, 2006; Jerhag & al, 2007). Interestingly, ghrelin also enhances the behavioural effects of cocaine (Wellman et al, 2005; Abizaid et al, 2012) suggesting that, in addition to increasing dopamine release, ghrelin also affects reuptake of dopamine at the level of the terminals (Abizaid, 2009). The research I intend to conduct during my Master’s degree will examine this hypothesis by investigating if ghrelin can alter dopamine transporters on the presynaptic membrane of dopaminergic neurons in the NAcc. Specifically, the hypothesis that will be addressed is whether ghrelin affects dopamine reuptake in the NAcc by directly affecting the internalization of DAT.

Poster Presentations

Rosenbaum, S., Jones, S. L., Gardener Gregory, J., Pfaus, J. G. (2012). Blocking aromatization facilitates sexual behavior in ovariectomized rats treated with estradiol and testosterone. CSBN/Psychology, Concordia University, Montréal, Québec, Canada. Poster presented at Society for Neuroscience, New Orleans, Louisiana, USA.

Jones, S. L., Roy, P., Gardner Gregory, J., Germé, K., Rosenbaum, S., Fox, R., Parada, M., Graham, D., Pfaus, J. G. (2012). Vaginocervical stimulation in the OVX Long-Evans rat attenuates sensitization of sexual behaviors following repeated administration of estradiol Benzoate alone. CSBN/Psychology, Concordia University, Montréal, Québec, Canada. Poster presented at Society for Behavioral Neuroendocrinology, Madison, WI, USA.

Madarulu, D., DiCarlo, A., Hantson, A., Hessing, N.J., Rosenbaum, S.,  Mumby, D. G., Brake, W.G. Effects of prefrontal cortical infusions of the dopamine D1 receptor antagonist, SKF38393, on working memory in the male rat. CSBN/Psychology, Concordia University, Montréal, Québec, Canada. Poster presented at Society for Neuroscience, New Orleans, Louisiana, USA.