Rim Khazall

  • PhD Student (Neuroscience)
  • Official Neuroscience 2011 (Washington, DC) Neuroblogger – Neurobites
  • Science Co-Chair – CU-WISE
  • Contact: email hidden; JavaScript is required
  • B.Sc. Neuroscience (Carleton University)

Research

I am interested in exploring the interaction of the orexigenic gut hormone ghrelin in response to stress, both chronic unpredictable and chronic social on female mice. Epidemiological studies clearly show that females are more vulnerable then males to experience stress-related psychopathologies, however animal and preclinical studies remain to be conducted on males. Literature has distinctly established that there is a gender difference with regards to vulnerability and response to stress. Ghrelin has also been shown to lower energy expenditure, and to increase body weight and adiposity. The potential interaction between ghrelin and stress may lead to the increase of calorie consumption, and in turn an increase in adiposity. Therefore, I will be also looking at the impact of ghrelin on obesity.

Publications

MacKay, H.A., Khazall, R., Patterson, Z.R., Wellman, M.K., Abizaid, A. (2013). Rats perinatally exposed to food restriction and high-fat diet show differences in adipose tissue gene expression under chronic caloric restriction. Adipocyte. 2(4): 1-9.

Blum ID., Patterson, Z., Khazall R., Lamont EW., Sleeman MW., Horvath TL. & Abizaid A. (2009) Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice. Neuroscience, 164 (2): 351-359.

Poster Presentations

Khazall, R., Rodrigues,T., Bashir, N., & Abizaid, A. Metabolic entrainment to scheduled meals and treats in relation to corticosterone and ghrelin. Society for Neuroscience. Washington D.C. US. November 12-16 2011.

Khazall, R., Rodrigues,T., Bashir, N., & Abizaid, A. Metabolic entrainment to scheduled meals and treats in relation to corticosterone and ghrelin. Symposium of Circadian Rhythms Research. Montreal, Quebec, Canada June 2- 3 2011.

Khazall, R.K., Wellman, M.K., Patterson, Z., Waddington Lamont, E., Mackay, H., Anisman, H., & Abizaid A.Effects of Ghrelin on Metabolic Processes in Response to Chronic Social Stress. Submitted to 2010 Canadian Association for Neuroscience, Ottawa, Ontario Canada May 15-18, 2010.

Khazall, R.K., Wellman, M.K., Lamont, E.W., Anisman, H,, & Abizaid A. Changes in GHSR expression in the VTA, Arcuate Nucleus, and Hippocampus in Response to Chronic Unpredictable Stress. .13th Annual Meeting of the Society for Behavioral Neuroendocrinology, East Lansing, MI, June 25-27, 2009.

Blum, I. D., Patterson, Z., Khazall, R., Waddington Lamont, E., Horvath, T. L., Sleeman, M., & Abizaid, A.Time for lunch! Ghrelin is an important signal for food anticipation. 13th Annual Meeting of the Society for Behavioral Neuroendocrinology, East Lansing, MI, June 25-27, 2009.

Patterson Z., Ducharme R., Khazall, R, Anisman, H., & Abizaid A. Ghrelin Mediates
the Metabolic Alterations Associated with Chronic Exposure to Stress
. 13th Annual Meeting for the Society for Behavioral Neuroendocrinology, East Lansing, MI, June 25-27, 2009.

Patterson ZR, Ducharme R., Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Contributes to the Development of Stress-Induced Metabolic Alterations Following Chronic Stress. Society for Neuroscience, 2009. Chicago, IL, USA.

Patterson ZR, Ducharme R., Khazall RK, Anisman H, Abizaid A. Ghrelin Mediates Metabolic Alterations Associated with Chronic Exposure to Stress. Young Researchers Forum – Institute of Mental Health Research, 2009. Ottawa, ON, Canada.

Patterson ZR, Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Mediates Vulnerability to Stress Induced Metabolic & Hormonal Dysfunction. Canadian Neuroscience Society, 2010. Ottawa, ON, Canada.

Patterson ZR, Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Mediates Vulnerability to Stress Induced Metabolic & Hormonal Dysfunction. Canadian Obesity Summit, 2010. Ottawa, ON.

Patterson ZR, Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Mediates Vulnerability to Stress Induced Metabolic & Hormonal Dysfunction. Society for Neuroscience, 2010. San Diego, California, USA.

Patterson ZR, Khazall RK, Sleeman MW, Anisman H, Abizaid A. Ghrelin Mediates Vulnerability to Stress Induced Metabolic & Hormonal Dysfunction. Society for Behavioral Neuroendocrinology, 2010. Toronto, ON, Canada.

Patterson ZR, Khazall,RK, Sleeman MW, Anisman H, Abizaid A. Differential Metabolic Profiles between Wild-Type and GHSR KO Mice Following Chronic Social Defeat Stress. Society for Neuroscience, 2011. Washington, DC, USA.

Mackay HM, Khazall R, Patterson ZR, Wellman M & Abizaid, A. Early Postnatal Over- or Under-Nutrition Affects FTO Expression in Adult Offspring. Young Researchers Forum – Institute of Mental Health Research, 2011. Ottawa, ON, Canada.

Mackay HM, Khazall R, Patterson ZR, Wellman M & Abizaid, A. Early Postnatal Over- or Under-Nutrition Affects FTO Expression in Adult Offspring. Young Canadian Obesity Summit Annual Meeting, Montreal, QU, Canada.

Smith CA, Wartman BC, Blum ID, Khazall RK, Moloney K, Patterson ZR, Wellman MK & Abizaid A.Neuroscience and the Arts: Society for Neuroscience Ottawa Chapter. Society for Neuroscience, 2011. Washington, DC, USA.

Associated Websites

  • Neurobites Blog – A blog created and written by both Harry and lab-mate Rim Khazall exploring the world of neuroscience. One of the official neuroblogs for Neuroscience 2011 in Washington, DC.
  • CU-WISE – Carleton University Women in Science and Engineering. Rim is the outreach executive.
  • Ottawa Fashion Week – Rim is the executive co-ordinator for Ottawa Fashion Week.